Polynerv Forte Mechanism of Action

Vitamins B₁, B₆ and B₁₂ are important factors in maintaining normal nerve metabolism. Any metabolic disorder that can result from the deficiency in these factors and or concomitant nerve injury can therefore cause peripheral neuropathies that usually present as sensory, motor and or autonomic impairment.
Since numbness and painful paresthesias often accompany peripheral neuropathies. Paracetamol, a proven safe and dependable analgesic coupled with B-complex supplementation can be employed to provide support in the management of the disease processes affecting neuromuscular system and their symptoms.
Thiamine (vitamin B₁) functions as a coenzyme of carbohydrate metabolism. It is specifically involved in the decarboxylation of alpha-ketoacids such as pyruvate and alpha-ketoglutarate. Impaired oxidation of the alpha-ketoacids leads to the accumulation of metabolites of the reaction, which are toxic to the cells of the central nervous system (CNS). Thus, thiamine promotes efficient metabolism of glucose and the conversion of glucose into other substances such as ribose, a major component of DNA and RNA. Thiamine activates production of energy from glucose and storage of energy as fat, making energy available to support normal cellular processes.
Thiamine is essential for the normal functions of the gastrointestinal, cardiovascular and nervous systems of the body. The smooth muscle cells of the heart, blood vessels, and the secretory glands of the gastrointestinal tract depend on the energy derived from metabolism of glucose, which thiamine catalyzes. A lack of thiamine leads to weakness in these smooth muscles. The cells of the CNS also depend exclusively on glucose as its source of energy. When there is thiamine deficiency, glucose utilization by nervous tissues decreases markedly, and communication in many different portions of the CNS is disrupted. Independent of its coenzyme function, thiamine also acts as a modulator in the transmission of neural impulses. Thiamine deficiency can cause degeneration of myelin sheaths in the peripheral nerves and in the CNS. This can lead to polyneuritis, a condition characterized by radiating pain along the course of one or more peripheral nerves.
Pyridoxine (vitamin B₆) participates in many cellular reactions of lipid and amino acid metabolism. The active form of B₆, pyridoxal phosphate, acts as a coenzyme in several metabolic transformations of amino acids, which are in turn needed for tissue building and repair, and in the synthesis of blood elements and certain compounds like neurotransmitters. Vitamin B₆ is required in the synthesis of delta-aminolevulinic acid, the precursor of heme, which is necessary for the formation of the hemoglobin molecule. Thus pyridoxine is essential for proper synthesis of red blood cells. Pyridoxine is also of particular importance in the synthesis of neurotransmitters, which are required for the normal activity of the nervous system. A deficiency of pyridoxine causes abnormal CNS function, with hyperirritability, neuritis, and even convulsions.
Polynerv Forte contains high amounts of cyanocobalamin (vitamin B₁₂), a coenzyme involved in several metabolic pathways. Among the important actions of cyanocobalamin is to act as a coenzyme of nucleic acid metabolism, reducing ribonucleotides to deoxyribonucleotides, a step that is essential in the replication of genes and formation of new cells, and the conversion of methylmalonyl CoA to succinyl CoA. Cyanocobalamin is likewise an important co-factor in the formation and maturation of red blood cells in the bone marrow.
Cyanocobalamin is also involved in the formation of myelin sheaths in nervous tissues. A deficiency causes demyelination of the large nerve fibers of the spinal cord. The inhibition of normal fatty acid synthesis in the brain and nerve tissues leads to faulty structure and impaired functions manifested as neurological symptoms.
Paracetamol relieves pain by blocking the production of prostaglandin, the chemical that causes pain, through the inhibition of the enzyme cyclooxygenase.